منابع مشابه
Insulin Resistance: Molecular Mechanism
Insulin resistance in skeletal muscle is present in humans with type 2 diabetes (non-insulin dependent diabetes mellitus) and obesity and in rodents with these disorders. Malonyl CoA is a regulator of carnitine palmitoyl transferase l (CAP I), the enzyme that controls the transfer of long chain fatty acyl CoA into mitochondria, where it is oxidized. In rat skeletal muscle, the formation of malo...
متن کاملMechanism of free fatty acid-induced insulin resistance in humans.
To examine the mechanism by which lipids cause insulin resistance in humans, skeletal muscle glycogen and glucose-6-phosphate concentrations were measured every 15 min by simultaneous 13C and 31P nuclear magnetic resonance spectroscopy in nine healthy subjects in the presence of low (0.18 +/- 0.02 mM [mean +/- SEM]; control) or high (1.93 +/- 0.04 mM; lipid infusion) plasma free fatty acid leve...
متن کاملCellular mechanism of insulin resistance in nonalcoholic fatty liver disease.
Insulin resistance is associated with nonalcoholic fatty liver disease (NAFLD) and is a major factor in the pathogenesis of type 2 diabetes. The development of hepatic insulin resistance has been ascribed to multiple causes, including inflammation, endoplasmic reticulum (ER) stress, and accumulation of hepatocellular lipids in animal models of NAFLD. However, it is unknown whether these same ce...
متن کاملMechanism of Insulin Resistance in Human Liver Cirrhosis
Insulin resistance in liver cirrhosis may depend on either reduced sensitivity (receptor defect) and/or reduced response to insulin (postreceptor defect). To clarify the mechanism of such resistance, a [3Hjglucose infusion (0.2 MuCi/min) was performed for 120 min before and during a euglycemic clamp at -100, 1,000, and 10,000 M&U/ml steady state plasma insulin concentration in 18 compensated ci...
متن کاملThe molecular mechanism linking muscle fat accumulation to insulin resistance.
Skeletal muscle insulin resistance is a co-morbidity of obesity and a risk factor for the development of type 2 diabetes mellitus. Insulin resistance is associated with the accumulation of intramyocellular lipids. Intramyocellular triacylglycerols do not appear to be the cause of insulin resistance but are more likely to be a marker of other lipid intermediates such as fatty acyl-CoA, ceramides...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
سال: 1999
ISSN: 0300-9173
DOI: 10.3143/geriatrics.36.389